Arterial stiffness and associated factors in non-diabetic pre-dialysis patients with chronic kidney disease
10.3760/cma.j.issn.1001-7097.2009.04.007
- VernacularTitle:慢性肾脏病非糖尿病非透析患者动脉僵硬度及其相关因素
- Author:
Mi WANG
;
Mei WANG
;
Lixia LU
;
Bing YANG
;
Sijun LI
;
Meng ZHANG
- Publication Type:Journal Article
- Keywords:
Kidney disease;
Kidney insufficiency,chronic;
Non-diabetic pre-dialysis;
Pulse wave velocity;
Vascular calcification
- From:
Chinese Journal of Nephrology
2009;25(4):277-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the arterial stiffness in non-diabetic pre-dialysis chronic kidney disease (CKD) patients and to explore the associated factors. Methods Automatic pulse wave velocity (PWV) measuring system was used to examine carotid-femoral pulse wave velocity (CFPWV) as the parameters reflecting central elastic large arterial elasticity. Vascular calcification was quantitatively evaluated by plain radiographic film of abdomen, pelvis and hands. Blood pressure, biochemical parameters and intact parathyroid hormone (iPTH) were routinely detected. Stepwise multiple linear regression analysis was used to assess the associated factors of arterial stiffness. Results Ninety-six non-diabetic pre-dialysis CKD patients and 30 healthy people were enrolled in this trial. CFPWV in stage 3, 4 and 5 CKD patients was significantly higher than that in healthy controls [(11.63±2.39) m/s, (11.70±2.80) m/s, (12.88±2.49) m/s vs (9.70±1.66)m/s , all P<0.05]. Stepwise multiple regression analysis demonstrated that age, mean arterial pressure, vascular calcification and iPTH were independent impact factors of CFPWV. Conclusions Arterial stiffness of large artery increases in non-diabetic pre-dialysis CKD patients. Age, mean arterial pressure, vascular calcification and iPTH are independent impact factors of CFPWV.
