Effects of treadmill training on the expression of Insulin-like growth factor-1 and its receptor in the brain of rats with focal cerebral ischemia
10.3760/cma.j.issn.0254-1424.2009.03.001
- VernacularTitle:跑台运动训练对脑缺血损伤大鼠胰岛素样生长因子-1及其受体表达的影响
- Author:
Yixian ZHANG
;
Nan LIU
;
Houwei DU
;
Ronghua CHEN
;
Jiehua WANG
;
Kexu LIN
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Rehabititative training;
Insulin-like growth factor-1;
Insulin-like growth factor-1 receptor
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(3):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of treadmill training on the recovery of neurological function and the expression of IGF-1/IGF-1Rin the brain poat focal cerebral ischemia.Metheods Forty-two male,adult Sprague-Dawley rats were randomly divided into a sham group(n=6),a model group(n=18)and a treadmill exercises group(n=18).Focal cerebral ischemia was induced in the latter two groups by right middle cerebral artery occlusion(MCAO)using a modified Longa's metheod.The rats in the treadmill exercises group were given treadmill training 6 days a week for 4weeks beginning 24 h after the MCAO. Rats in the sham group and model groups were reared in standard cages and could move frddly. Before being sacrificed at the 7th 14th and 28th day after the MCAO,the rats' neurological function were tested giving modified neurological weverity scores (mNSS). The expression of IGF-1/IGF-1R was detected using the reverse transcriptsae polymersae chain reaction and immunohistochemical methods.Results Neurological runction in the exercises group at the 14th and 28th day was better than in the control group,and IGF-1 and IGF-1Rexpression were significcantly upregulated on the 7th,14th and 28th day after the MCAO.Conclusion Treadmill training can improve neurological function by upregulating the expression of IGF-1 and IGF-1R in the ischemic brain, at least in rats.
