Relationship between multiresistance and efflux system of Acinetobacter baumannii
10.3760/cma.j.issn.0254-5101.2009.03.015
- VernacularTitle:鲍曼不动杆菌多重耐药性与主动外排机制的相关性研究
- Author:
Jingping ZHANG
;
Wan ZHU
;
Yunzhuo CHU
;
Sufei TIAN
;
Baiyi CHEN
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Muhiresistance;
Efflux pump
- From:
Chinese Journal of Microbiology and Immunology
2009;29(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the encoding gene of efflux pump and two-component system, and investigate the effect of efflux inhibition on the multiresistance of Acinetobacter baumarmii. Methods PCR was used to detect the adeB, adeR and aries gene. Agar dilution was used to determine the minimum inhibitory concentrations(MIC) of ciprofloxacin, cefotaxime, amikacin and imipenem of 50 multiresistance Acinetobacter baumannii, with or without 25 μg/ml reserpine. Results 94%, 96% and 92% of 50 muhiresistance of Acinetobacter baumannii were detected for adeB, adeR and aries gene,respectively. At least four fold decrease of MIC was observed in 49, 50, 50 and 46 isolates for ciprofioxacin, cefotaxime, amikacin and imipenem, respectively. Conclusion The multiresistance of Acinetobacter baumannii is related to the effect of the efflux system.
