Electroacupuncture and the expression of neuropeptides in the callus formed after femoral fracture

VernacularTitle:电针对股骨骨折大鼠骨痂内神经肽表达水平的影响
Author: Xin WANG ; Lugang ZHOU ; Hongzhi LIU ; Lei WANG ; Yujie SUN ; Hao SU
Publication Type:Journal Article
Keywords: Neuropeptides; Electroaeupuncture; Callus; Femoral fracture
From: Chinese Journal of Physical Medicine and Rehabilitation 2009;31(4):245-248
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of electroacupuncture on the expression of neuropeptides in fibroeartilage callus tissue after femoral fracture. Methods Forty male Wistar rats were randomly divided into a fracture group and an electroacupuncture group. Femoral fracture models were established in both groups, and the rats in the electroacupuncture group were given electroacupuncture. Rats were sacrificed on the 4th, 7th, 14th and 28th days after surgery. The calluses were stained immunohistochemically to detect the expression of calcitonin gene-related peptide (CGRP) and substance P (SP). Results CGRP and SP levels increased rapidly after eleetroacu-puncture, with neuropeptides expressed strongly in callus cell tissue. The optical density (OD) in the electroacu-puncture group was significantly higher than that in the fracture group ( P≤0. 05 ). Conclusion Electroaeupune-ture can significantly increase the expression of neuropeptides in rats after femoral fracture. Electroaeupuneture can promote fracture healing through regulating neuropeptides.