Endoscopic ultrasonography-guided fine-needle aspiration in diagnosis of pancreatic cancer
10.3760/cma.j.issn.1007-5232.2009.04.005
- VernacularTitle:内镜超声引导下细针穿刺抽吸术对胰腺癌的诊断价值
- Author:
Xiaoping ZOU
;
Bin ZHANG
;
Wen LI
;
Zhaomin XU
- Publication Type:Journal Article
- Keywords:
Endoscopic uhrasonography;
Aspiration biopsy,fine-needle;
Pancreatic cancer
- From:
Chinese Journal of Digestive Endoscopy
2009;26(4):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of endoscopic ultrasonography-guided fineneedle aspiration(EUS-FNA)for pancreatic occupying lesion,especially pancreatic cancer.Methods From year of 2005,37 patients with suspected pancreatic cancer by means of uhrasound,CT or MRI received EUS-FNA.Amylase and tumor markers(CEA,CA19-9 and CA125)in cyst fluid were analyzed if applicable.The patients were followed up till July 2008,and the results of EUS-FNA were compared with those confirmed during the follow-up.Results The EUS-FNA yielded diagnosis of 16 cases of pancreatic duetal adenocarcinoma,1 metastatic:renal cancer,5 suspicious malignancy,6 atypia,6 normal pancreatic tissue,and 3 normal non-pancreatic tissue.During the follow-up,25 cases of pancreatic cancer and 10 benigh lesions,including 4 chronic panereatitis,4 cyst-adenoma and 2 pseudocyst,were confirmed,and the other 2 cases still remained un-determined.The sensitivity,specificity,positive predictive value and negative predictive value of EUS-FNA were 80.0%(95% CI:59.0-93.0),100.0%(95% CI:60.0-100.0),100.0%(95% CI:80.0-100.0),and 55.6%(95% CI:27.0-79.0),respectively.No severe procedurerelated complication was observed.Conclusion EUS-FNA is a safe and effective medality for diagnosis of pancreatic occupying lesions,especially pancreatic cancer.
