Association between polymorphisms of B7-H4 gene and the risk of sporadic breast cancer in Heilongjiang Province
10.3760/cma.j.issn.1006-9801.2009.04.006
- VernacularTitle:B7-H4基因多态性与黑龙江省乳腺癌易感性的研究
- Author:
Dalin LI
;
Jie ZHANG
;
Zhenkun FU
;
Minyan ZHANG
;
Fengyan XU
;
Da PANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Polymurphism,single nucleotide;
Disease susceptibility
- From:
Cancer Research and Clinic
2009;21(4):232-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between the polymorphisms of BT-H4 gene and the risk of breast cancer, a case-control study was conducted in the population of Heilongjiang province, China. Methods We genotyped the single nucleotide polymorphisms of rs10754339, rs10801935 and rs3738414 in B7-H4 gene by PCR-RFLP in a Chinese population consisting of 287 breast cancer cases and 305 controls matched for age and sex, tagged all common haplotypes (frequency ≥ 1%), and analyzed the differences between patients and normal controls. Results Our data indicated that in rs10754339, the frequencies of G allele, AA genotype and AG genotype were significantly different between patients and controls (P=0.030, OR 1.359, 95 % CI 1.030-1.794; P=0.018, OR 0.671, 95 % CI 0.482-0.935; P=0.029, OR 1.455, 95 % CI 1.038-2.038, respectively). In rs3738414, the frequencies of A allele, GG genotype and AG genotype were significantly different between patients and controls (P=0.0008, OR 0.604, 95 % CI 0.455-0.803; P=0.001, OR 1.804, 95 % CI 1.289-2.253; P=0.005, OR 0.612, 95 % CI 0.435-0.862). The frequencies of AAA haplotype and GAG haplotype were significantly different between patients and controls (P=0.0015, OR 0.614, 95 % CI 0.456-0.828; P=0.0003, OR 1.954, 95 % CI 1.363-2.803). Conclusion Polymorphisms of B7-H4 gene appear to be associated with breast cancer in the population of Heilongjiang province, China.
