The clinical significance of pathologic typing of colorectal adenocarcinoma and its prognostic analysis
10. 3760/cma:j. issn::0254-1432. 2009.04. 009
- VernacularTitle:结直肠腺癌病理分型的临床意义及预后分析
- Author:
Wu SONG
;
Yulong HE
;
Shirong CAI
;
Changhua ZHANG
;
Chuangqi CHEN
;
Xinhua ZHANG
;
Jianjun PENG
;
Wenhuan ZHAN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Adenocarcinoma,mucinous;
Carcinoma,signet ring cell
- From:
Chinese Journal of Digestion
2009;29(4):249-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological difference and prognosis of colorectal adenocarcinomas including mutinous, Signet-ring cell, papillary and tubular carcinomas. Methods Two thousand and eighty-nine patients with colorectal cancer underwent colorectal operation between August 1994 and April 2007. The clinicopathological characteristics of mucinous adenocarcinoma (n=144), signet-ring cell carcinoma (n=25), papillary and tubular carcinomas (n= 1837) were compared expect of other types of cancer (n = 83). The single factor and Logistic regression methods were used to analyze the clinicopathological parameters that influence the prognosis of colorectal cancer such as age, location of the tumor, staging, peritoneum and pathological typing. The survival rates of patients with above three types of adenocareinomas were analyzed. Results The mean age of onset was lowest in patients with mutinous adenocarcinomas [(54. 20 ± 16.25) years] compared with that in patients with signet-ring cell cancer [(40.43 ± 12.88)years] or papillary and tubular carcinomas [(58. 73 ±13.62)]. There were significant differences in gender, size and location of the tumor, TNM staging, peritoneal metastasis, lymph node involvement and adjacent organ invasion among three groups (all P values <0.05). The single factor and Logistic regression analysis revealed that both mucinous adenocarcinoma and signet-ring cell carcinoma were risk factors ot prognosis. The patients with mucinous adenocarcinoma or signet-ring cell tumor were poor in long-term overall survival in comparison with patients with papillary and tubular carcinoma (P<0. 001). Conclusions The colorectal mucinous and signet-ring cell adenocarcinomas are risk factors for prognosis of colorectal cancer, which imply the poor outcome.
