Establishment of portal hypertension induced esophageal varices in canine by ameroid coustrictor

VernacularTitle:门静脉收缩器建立犬门静脉高压食管静脉曲张模型的实验研究
Author: Bin SUN ; Janming XU ; Qiru XIONG ; Zhengguang WANG ; Chao ZHANG
Publication Type:Journal Article
Keywords: Esophageal and gastric varices; Models,animal; Portal pressure
From: Chinese Journal of Digestive Endoscopy 2009;26(3):144-147
CountryChina
Language:Chinese
Abstract: Objective To establish the canine model of esophageal variees caused by portal hyper-tension. Methods The model was established in 12 dogs with a side-to-side portacaval shunt, an ameroid constrictor around the portal vein and double ligation and cross suture of the cephalic part of the inferior vena cava (IVC), and the development of esophageal varices was confirmed 6 weeks later by endoscopy and portal vein angiography. Results The mean pre- and postoperative portal pressure were (11.0 ± 1.1) mm Hg and (22. 9 ± 1.2) nun Hg, respectively (P =0. 010). Endoscopy detected mild to moderate esophageal varices in all dogs, which was confirmed by portal vein angiography, and varices was also seen in abdominal wall. Conclusion Canine model of esophageal varices induced by portal hypertension can be established with the procedure.