Diagnostic value of free plasma metanephrines for pheochromocytoma
10.3760/cma.j.issn.1009-9158.2009.05.032
- VernacularTitle:血浆游离甲氧基肾上腺素水平在诊断嗜铬细胞瘤中的价值
- Author:
Yunchao GAO
;
Hankui LU
;
Quanyong LUO
;
Libo CHEN
;
Ying DING
;
Ruisen ZHU
- Publication Type:Journal Article
- Keywords:
Adrenal gland neoplasms;
Pheochromocytoma;
Metanephrine;
Enzyme-linked immunosorbent assay
- From:
Chinese Journal of Laboratory Medicine
2009;32(5):535-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of free plasma metanephrines metanephrine(MN) and normetanephrine (NM) measured with enzyme immunoassay (EIA), NM in diagnosis of pheochromocytoma. Methods Histologically confirmed pheochromocytomas (n=30) and control patients with hypertension (n=51) were enrolled in the study. Blood tests for free plasma metanephrines(MN and NM) were performed with a commercially available EIA kit and the results were compared with [3] I-metaiedobenzyl guanidine (MIBG) whole body scan findings. Results The whole body scan was positive in all pheochromocytoma patients and negative in 15 control patients with 100% accuracy. The median values in the 2 groups were 59.3 ng/L and 33.7 ng/L (Z=-2. 440, P<0.05) for MN, 652.0 ng/L and 36. 3 ng/L (Z=-6.699, P<0.001) for NM, with 96. 7% (29/30) sensitivity, 86. 3% (44/51)specificity and 90.1% (73/81) accuracy for their combination ( either or both positive). There was no significantly statistical difference when compared with 13I-MIBG whole body scan findings (100. 0% ,P >0. 05). Conclusion The results show that the EIA method may be eligible as an alternative to HPLC for plasma metanephrines determination in the identification of pheochromocytoma.
