Detection of apoptotic inhibitor gene Livin in esophageal cancer by real-time fluorescence quantitative PCR and its clinical significance
10.3760/cma.j.issn.1006-9801.2009.05.010
- VernacularTitle:荧光定量PCR法检测食管癌中Livin基因的临床研究
- Author:
Zhendong HAN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Atypical hyperplasia;
Livin gene;
Real-time fluorescence quantitative PCR
- From:
Cancer Research and Clinic
2009;21(5):317-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of apoptotic inhibitor gene Livin in different esophageal epithelial lesions and to analyze the relation between the expression of Livin with pathologic characteristics. Methods The expressions of Livin mRNA were detected by real-time fluorescence quantitative PCR in 40 patients with different esophageal epithelial lesions including normal, atypical hyperplasia, carcinoma in situ and invasive carcinoma. Results The expression of Livin was progressively increased from normal to invasive carcinoma. Conclusion The expression of Livin is significantly related to the progression of esophageal cancer. The detection of Livin by real-time fluorescence quantitative PCR may be a reliable means for early diagnosis of esophageal cancer.
