Therapeutic effects analysis of patients with stage Ⅲ gastric carcinoma administrated fluorouracil implants during radical gastrectomy
10.3760/cma.j.issn.1006-9801.2009.05.018
- VernacularTitle:氟尿嘧啶植入剂在Ⅲ期胃癌患者根治术中的应用
- Author:
Hongzhi LUO
;
Zonghai HUANG
;
Yuaulong YU
;
Hong CHEN
;
Huizhou DENG
- Publication Type:Journal Article
- Keywords:
Drug implants;
Stomach neoplasms;
Surgical procedures operation
- From:
Cancer Research and Clinic
2009;21(5):338-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of fluorouracil implants in Stage Ⅲgastric carcinoma patients after radical gastreetomy. Methods The general state of health and cumulative survival of 200 stage Ⅲ gastric carcinoma patients undergone radical gastrectomy from January, 1999 to, December 2002 in the People's Hospital of Zhongshan City were analyzed, in which only 120 patients administrated fluorouracil implants during radical gastreetomy. The therapeutic effects of fluorouracil implants in stage Ⅲ gastric carcinoma patients after radical gastrectomy were observed. Results The differences of weight (P = 0.041), HGB(P =0.024), Plt(P =0.017), CEA(P =0.001), CA19-9(P =0.003) were significant between two groups. The incidence rate of nausea/emesis in group T (28 %) was higher than that in group O(17 %, P = 0.006), and incidence rates of myelosuppression(P =0.81), diarrhea(P =0.72), hepatic function lesion(P =0.97) and renal function lesion(P =0.20) were no significant. The cumulative 5-year survival rate of group T(45 %) was higher than that in group O (15 %, P =0.002). Conclusion Fluorouracil implants can improve the therapeutic effects on gastric carcinoma patients undergone radical gastrectomy.
