Eleetroacupuncture and the immunological inflammatory reaction in the frontal lobe seen with Alzheimer's disease
10.3760/cma.j.issn.0254-1424.2009.04.006
- VernacularTitle:电针对阿尔茨海默病大鼠额叶免疫炎性反应的调节作用
- Author:
Shuxiu ZHU
;
Aini FU
;
Guojie SUN
- Publication Type:Journal Article
- Keywords:
Electroacupuncture;
Alzheimer's disease;
Microglia;
IL-1β;
Tumor necrosis faetor-α
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(4):236-238
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive To observe the effect of electroacupuncture (EA) on microglia, interleukin-1β, and tumor necrosis factor-or (TNF-α) in the frontal lobes of rats modeling Alzheimer's disease (AD). Methods Forty-eight normal SD rats 24 months old were randomly divided into a normal group, a sham operated group, a model group and an EA group, with 12 rats in each group. The AD model was established by stereotaxic microinjection of agglutinated amyloid-beta protein (A1β-40, 1 μl, 10 μg/μl) into the rats' bilateral Meynert nucleus. The effects of EA applied to the rats' "Baihui" ( DU 20) "Taixi" ( KI 3 )" and "Zusanli" ( ST 36) acupoints were observed. The EA treatment was applied once a day for 6 days as a course. The next course of treatment was continued after one day's rest and the total treatment involved 2 courses. The activated mieroglia and the expression of IL-1β, and TNF-α in the frontal lobe were determined by immunohistochemistry method. Results The number of cells exhibiting microglia, IL-1β, or TNF-α in the frontal lobes of rats in the model group increased significantly, but after EA treat-ment, cells showing microglia, IL-1β, or TNF-α decreased remarkably. There were significant differences in compar-ison with the model group (P≤0. 01). Conclusion Electroacupuncture treatment can depress inflammatory reac-tion in the frontal lobe of AD rats and adjust the rats' immunologic state.
