The effects of hyperbaric oxygen on serum matrix metalloproteinase-9, intercellular adhesion moleeule-1 and brain edema in patients with intraeerebral hemorrhage
10.3760/cma.j.issn.0254-1424.2009.04.014
- VernacularTitle:高压氧对脑出血患者血清基质金属蛋白酶-9、细胞问黏附分子-1及脑水肿的影响
- Author:
Xiangyang ZHU
;
Zhengxie DONG
;
Yong ZHOU
;
Jia LI
;
Lianhai ZHU
;
Shenchu GONG
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
lntracerebral hemorrhage;
Brain edema;
Magnetic resonance;
Ma-trix metalloproteinase-9;
Intercellular adhesion molecule-1
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(4):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen (HBO) therapy on serum matrix met-alloproteinase-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) levels, and on brain edema in patients with intracerebral hemorrhage. Methods Seventy-six subjects with intracerebral hemorrhage were divided into a routine treatment group (40 cases) and a.HBO treatment group (36 cases). 30 healthy persons served as a control group. Serum MMP-9 and ICAM-1 levels were measured before and after treatment. MRI images of the subjects' brains were prepared at the 5 ～ 7 th and 25th days. Absolute edema volumes and relative edema volumes were meas-ured on T2-weighted images. Results (1)The serum MMP-9 and ICAM-1 levels in the routine therapy and HBO groups were higher than those in the control group at the outset ( P≤0. 01 ). Both indices peaked on the 5th day, but there was no significant difference between the two treated groups. At the 15th and 25th day (after 10 and 20 HBO treatments) , the serum MMP-9 and ICAM-1 levels in the HBO group had decreased remarkably and were significant-ly lower than those in the routine therapy group (P≤0. 01 ). (2)At the 5 -7th and 25th days, both absolute edema volumes and relative edema volumes in the HBO group were significantly smaller than those in the routine therapy group ( P≤0. 05, P≤0. 01 ). (3) Serum MMP-9 and ICAM-1 levels were positively correlated with the brain edema volumes, and negatively correlated with decreased NIHSS scores (between pre- and post-treatment). Conclusions HBO therapy may reduce serum MMP-9 and ICAM-1 levels in patients with intracerebral hemorrhage, and lessen the severity and range of brain edema. HBO is helpful for restoring nerve function. Early and repeated multiple HBO treatments are beneficial for patients.
