Expression of aquaporin-1,3,8,9 mRNA in human amniotic membranes in polyhydranmios
10.3760/cma.j.issn.1007-9408.2009.03.011
- VernacularTitle:羊水过多孕妇胎膜组织中水通道蛋白-1、3、8、9 mRNA的表达
- Author:
Huishu LIU
;
Rongzeng HAO
;
Zhengfang XIONG
- Publication Type:Journal Article
- Keywords:
Aquaporins;
Gene expression;
Polyhydramnios;
Extraembryonic membranes
- From:
Chinese Journal of Perinatal Medicine
2009;12(3):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of aquaporin-1,3,8,9 mRNA (AQP-1,3,8, 9) in amniotic membranes in pregnant women with polyhydramnios. Methods Amniotic membranes were collected from women who presented with either polyhydramnios (n= 5)or normal amniotic fluid volume (control, n= 5) underwent elective cesarean sections at term. The AQP-1,3,8,9 mRNA expression were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Results The expression of AQP-9 mRNA on fetal membranes were significantly higher in polyhydramnios groups (1. 1403±0. 0831) than that of control (0. 5903±0. 1909) (P = 0. 002), although the expression of AQP-1, 3 and 8 showed no significant difference between the two groups (P= 0. 972, 0. 242,0. 608, respectively). Conclusions AQP-9 may play an important role in maintaining the volume and the balance of different components of amniotic fluid in polyhydramnios cases.