Study on the association of 3'UTR polymorphisms of NRAMP1 gene with susceptibility to tuberculosis in Uighurs

VernacularTitle:NRAMP1基因3'UTR多态性与新疆维吾尔族人群结核病易感性的相关性研究
Author: Xianjie MENG ; Fangtao WU ; Dong YAN ; Xia WANG ; Chunzhu LI ; Fang WU ; Ping WANG ; Jiangdong WU ; Wanjiang ZHANG
Publication Type:Journal Article
Keywords: Polymorphisms; NRAMP1 gene; Disease susceptibility; Tuberculosis
From:Chinese Journal of Microbiology and Immunology 2009;29(5):420-423
CountryChina
Language:Chinese
Abstract: Objective To determine whether 3'UTR polymorphisms of the NRAMP1 gene are as-sociated with tuberculosis in Uighurs. Methods 3'UTR polymorphisms of NRAMP1 gene were typed by PCR-RFLP among 224 patients with active tuberculosis and 225 healthy individuals. The relationship be-tween 3'UTR polymorphisms and susceptibility to tuberculosis was studied, and cases were grouped accord-ing to genotypes. Results In the tuberculosis patients, genotype TGTG/TGTG,TGTG/TGTG deleted, and TGTG deleted/TGTG deleted were observed in 159,56 and 9 cases respectively, while the genotypes of the healthy controls were TGTG/TGTG in 185, TGTG/TGTG deleted in 36 and TGTG deleted/TGTG deleted in 4 case. The frequency of the genotype TGTG/TGTG was found more often among controls than that in pa-tients (X2=7.94 ,P <0.01). The frequency of allele TGTG and the frequency of variant allele were 0.87 and 0.13 respectively. Conclusion 3'UTR polymorphisms of NRAMP1 gene are associated with suscepti-bility to tuberculosis in Uighurs.