The role of Survivin and VEGF in angiogenesis of colorectal tumor

VernacularTitle:Survivin与VEGF在结直肠肿瘤血管形成中的作用
Author: Wenyuan WANG ; Bo JIANG ; Yi FENG ; Xiaobo LIANG
Publication Type:Journal Article
Keywords: Colorectal neoplasms; Survivin; Vascular endothelial growth factors; Angiogenesis
From: Cancer Research and Clinic 2009;21(5):320-322
CountryChina
Language:Chinese
Abstract: Objective To identify the role of survivin and VEGF in angiogenesis of colorectal tumor by investigating tissue expression of survivin, VEGF and CD34 in human colorectal tumors. Methods Immunohistochemical staining for the paraffin sections by using the polyclonal antibodies of survivin, monoclonal antibodies of VEGF and CD34, was performed by the standard avidin-biotin-peroxidase technique. The percentage of positive cell and quantitative analysis were made by image analysis system, which also helped to calculate the amount of MVD. Results The immunoreactivity of survivin significantly increased in the transition from adenoma with low dysplasia to adenoma with high dysplasia (P <0.01). Similar changes in protein expression were observed for VEGF and MVD. The expression of survivin was closely related with that of VEGF. Both were positively correlated with MVD. Conclusion Survivin promotes angiogenesis of colorectal tumor together with VEGF. VEGF may be the potential causes of reexpression of survivin during colorectal tumorigenesis.