Effects of isoniazid and pyrazinamide on bioavailability of rifampicin when co-administered rifampicin-isoniazid
- Author:
Nguyen Thi Lien Huong
- Publication Type:Journal Article
- Keywords:
Rifampicin;
Isoniazid;
Pyrazinamid;
Bioavailabilities;
Effects
- MeSH:
Tuberculosis;
Tuberculosis, Multidrug-Resistant;
Pyrazinamide;
Rifampin;
Biological;
Availability
- From:Journal of Medical Research
2005;36(3):12-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study was conducted to compare bioavailability of rifampicin at the same doses with and without isoniazid and pyrazinamide in the standard separate tablets in 12 healthy volunteers. Bioavailability of rifampicin was estimated by plasma concentration of rifampicin from 0h to 24h after administration. Plasma rifampicin concentration was determined by HPLC method. The results revealed that Cmax and AUC for rifampicin was reduced (31.24% and 25.95%, respectively) when rifampicin - isoniazid - pyrazinamide was administeredat the same time. It was concluded that bioavailability of rifampicin was affected by presence of isoniazid and pyrazinamide.
