Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease.
- Author:
Xiaoli SI
1
;
Jiali PU
;
Baorong ZHANG
Author Information
- Publication Type:Review
- Keywords: Parkinson's disease; alpha-synuclein; pathogenic mechanism; biomarker; therapeutic strategy
- MeSH: alpha-Synuclein; Alzheimer Disease; Dopaminergic Neurons; Lewy Bodies; Neurodegenerative Diseases; Parkinson Disease*
- From:Journal of Movement Disorders 2017;10(2):69-79
- CountryRepublic of Korea
- Language:English
- Abstract: Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
