Decreased mRNA expression of death receptor(DR)-4 in the leiomyoma tissues

VernacularTitle:子宫肌瘤中细胞凋亡受体mRNA表达水平分析
Author: Xiaohong LI ; Yu WANG ; Xiaoqi LI ; Shijun ZHENG
Publication Type:Journal Article
Keywords: Neoplasms; Uterine neoplasms; Apoptosis
From: Cancer Research and Clinic 2009;21(2):117-119
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of leiomyoma with death receptors(DR) and the mechanisms underlying the development of leiomyoma.Methods The semi-quantitative RT-PCR was employed to examine the mRNA expression of apoptosis-associated death receptors in the Leiomyoma tissue samples collected from 20 clinical cases.Results It was found that the mRNA expression of DR4 in leiomyoma tissue was dramatically decreased as compared to that of normal tissue controls (P<0.001),but no difference was found between leiomyoma and normal tissue controls in terms of DcR1,DcR2,DR5,TNFR1A,TNFR1B and Fas mRNA expressions (P>0.05).Conclusion It is highly possible that DR4 expression might be involved in the development of leiomyoma.More efforts will be required to elucidate the exact mechanisms underlying the development of leiomyoma.