Clinical value of combined detection of tumor markers for nasopharyngeal carcinoma and squamous cell carcinoma in head and neck

VernacularTitle:头颈部鳞状细胞癌血清SCC、CYFRA21-1、NSE、CEA联合检测的临床意义
Author: Jisheng WANG ; Yan SUN
Publication Type:Journal Article
Keywords: Head and neck neoplasms; Nasopharyngeal neoplasms; Radiotherapy,computer-assisted; Tumor markers,biological
From: Cancer Research and Clinic 2009;21(6):396-398
CountryChina
Language:Chinese
Abstract: Objective To study the clinical value of serum SCC,CYFRA21-1,NSE and CEA for patients with nasopharyngeal carcinoma (NPC) and squamous cell carcinoma of head and neck (NHSCC). Methods From Aug 2004 to Sep 2007, the serum levels of SCC, CYFRA21-1, NSE and CEA were detected in 79 NPC and 51 HNSCC before and after radiotherapy. The clinical related factors were analyzed. Results Before treatment, the positive rates of serum SCC, CYFRA21-1, NSE and CEA for patients with NPC were 10.53 %, 46.75 %, 17.5 % and 2.04 %, respectively. The sensitivity of combined detection was 78.95 %. The positive rates for patients with HNSCC were 22 %, 19.75 %, 11.11% and 0, respectively. The sensitivity of combined detection was 36.17 %. The level of SCC was related to staging in HNSCC group. CYFRA21-1 was related to the rote of treatment response in NPC group. Conclusion The sensitivity of combined detection of tumor markers were significantly increased. CYFRA21-1 associated with NPC and SCC with HNSCC were noted in this study.