The effects of rehabilitation on learning,memory and expression of NCAM in rats with vascular dementia
10.3760/cma.j.issn.0254-1424.2009.06.001
- VernacularTitle:康复训练对血管性痴呆大鼠学习记忆能力及海马区神经细胞黏附因子表达的影响
- Author:
Zhenyong FAN
;
Lina CHEN
;
Linfeng XU
;
Ya ZONG
;
Jianyong HU
;
Xianghua YU
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
Rehabilitation training;
Learning and memory;
Neural cell adhesion molecule
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(6):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rehabilitation training on learning and memory ability and the expression of neural cell adhesion molecule(NCAM)in rats modeling vascular dementia.Methods Foay-five female Sprague-Dawley rats were randomly assigned to a rehabilitation group(20 rats),an immobilization group(20 rats),or a sham-operation group(5 rats).The experimental vascular dementia model was established by repeatedly clipping the common carotid artery to induce repetitive isehemia-reperfusion,and by reducing blood pressure with intra-abdominal injection of sodium nitroprusside.The rats' learning and memory were tested on the 27th and 28th days after the operation using a water-maze step-down avoidance test.A RT-PCR technique was used to detect NCAM expression around the hippocampal area at different times after the operation.Results The rehabilitation group rats showed significantly better learning and memory ability than those in the immobilization group.NCAM was also more strongly expressed in their hippocampi than in those of the immobilization group and sham-operation group.Conclusion Rehabilitation can accelerate recovery of learning and memory ability in rats,and the mechanism possibly is related to the increase of NCAM expression in the hippocampus.
