Transplantation of autologous bone marrow stem cells in treatment of patients with decompensated cirrhosis
10.3760/cma.j.issn.0254-1432.2009.07.001
- VernacularTitle:自体骨髓干细胞移植治疗失代偿期肝硬化
- Author:
Xiaozhong GUO
;
Di WANG
;
Xiaodong SHAO
;
Jiajun ZHAO
;
Hongyu LI
;
Zhongmin CUI
;
Feng LIU
- Publication Type:Journal Article
- Keywords:
Hcmatopoietic stem cell transplantation;
Transplantation,autologous;
Liver cirrhosis
- From:
Chinese Journal of Digestion
2009;29(7):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of autologous bone marrow stem cells transplantation in treatment of patients with decompensated cirrhosis. Methodls Seventy-eight patients (aged from 26 to 67) with decompensated cirrhosis, including 56 with hepatitis B, 21 with alcoholic cirrhosis and 1 with schistosomial cirrhosis, were included. Bone marrow was aspirated from poster superior spine. After isolation and purification, the stem cells were transplanted into liver via hepatic artery. The liver function, laboratory parameters and Child-Tureotte-Pugh scores were evaluated in 2,4 and 8 weeks after transplantation. Results At the 4th week after transplantation, the level of albumin was increased obviously from (32.9±5.58) g/L to (38.32±6.45) g/L,whereas the alanine aminotransferase was decreased from (96.92±83.91) U/L to (73.48±18.46)U/L. It was revealed that the prothrombin time was decreased from (16.66±3.91) s to (15.52±3.35) s and fibronegen increased from (2. 22 ± 0. 88) g/L to (2. 58±0. 88) g/L. After transplantation, appetite was improved in 72 cases (92.3%), ascites was decreased in 70 cases (89.7%) and abdomen distention was ameliorated in 68 cases (87.2%). There was no complications related to the transplantation. Conclusion Transplantation of autologous bone marrow stem cells is a safe and effective method in treatment of patients with decompensated cirrhosis.
