The detection and clinic significance of platelet activation of bronchial lung cancer
10.3760/cma.j.issn.1006-9801.2009.06.015
- VernacularTitle:支气管肺癌患者血小板活化状态检测的临床意义
- Author:
Aihua ZHANG
;
Wenli LIU
;
Wenning WEI
;
Lei WANG
;
Dachun SUN
;
Xiaoliang LI
;
Delu TANG
;
Kairong TIAN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Platelet activation;
Platelet adhesiveness;
Flow cytometry
- From:
Cancer Research and Clinic
2009;21(6):406-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adhesion molecule expression and functional status of platelets in lung cancer patients, and their relations with disease progression. Methods Using flow cytometry to measure the expression of surface antigens and functional status of platelets in 60 healthy control group, and 164 lung caneer patients. Results Comparing with control group, the expression in early group and mid term group(A group) of CD31, CD36, CD62, CD63 increased, and there is no significant meaning in the differences of surgery group (B group) of CD31, TSP, CD36, CD62, CD63. The expression in advanced group (C group) of CD31, TSP, CD36, CD62, CD63 increased. Comparing with A Group, the expression in B Group of CD36, CD62, CD63 decreased. The expression in C group of CD31, TSP, CD36, CD62, CD63 increased. Comparing with the small cell lung cancer, the expression of adenocareinorna of TSP, CD36,, CD62, CD63, squamous cell carcinoma of CD31, CD62, CD63, and alveolus cancer of CD31, TSP, CD63, all decreased. Conclusion The high level expression of platelet activation exists in patients with lung cancer of different stage, and decreased after operation. Platelet activation expressed significantly in the advanced stage of small cell lung cancer.
