The resistance mechanism and response prediction of docetaxel
10.3760/cma.j.issn.1006-9801.2009.06.027
- VernacularTitle:多西紫杉醇耐药机制与疗效预测的研究进展
- Author:
Li XIE
;
Jia WEI
;
Baorui LIU
- Publication Type:Journal Article
- Keywords:
Docetaxel;
Drug resistance,neoplasm;
Treatment outcome;
Research
- From:
Cancer Research and Clinic
2009;21(6):427-429
- CountryChina
- Language:Chinese
-
Abstract:
Resistance is one of the most important reasons that restrict the clinical application of most chemotherapeutic medicines. Docetaxel is a very widely applicated antitumor medicine. Most of the researches on the mechanism of resistance against docetaxel focused on the drug transporters, changes in drug metabolism and pathway alteration of cell cycle and apoptnsis. The mechanism of docetaxel resistance and the predictive data based on clinical research to docetaxel therapy in cancer treatment were reviewed.
