Different serum proteins were found between early-stage and late-stage lung cancer patients by using proteinchip technology

VernacularTitle:应用蛋白质芯片技术筛选早中期和晚期肺癌患者血清差异蛋白
Author: Ruifen TIAN ; Sutang GUO ; Xia SONG ; Yi GUO ; Ruihong YANG ; Xia ZHANG
Publication Type:Journal Article
Keywords: Lung neoplasms; Proteomics; Neoplasm metastasis
From: Cancer Research and Clinic 2009;21(8):466-468
CountryChina
Language:Chinese
Abstract: Objective To test serum differentially expressed proteins between early-stage (stage IB-ⅢA) and late-stage (stage Ⅳ) lung cancer patients by proteinchip technology and investigate its clinical value. Methods SELDI-TOF-MS and WCX-2 protein chip were used to detect the serum protein of 30 cases of early stage lung cancer patients and 30 cases of late stage lung cancer patients. The data were analyzed by using Biomarker Wizard software. Results There are ten different proteins in the serum between the two groups of lung cancer patients. Four protein markers 7978, 8139, 15 951 and 16 133 are over expressed and seven protein markers 2867, 6885, 8701, 8840, 13 781 and 13 955 are low expressed in the late group. Conclusion SELDI-TOF-MS proteinchip technology is a convenient, sensitive and high-throughput analysis method which can screen several relatively specific protein markers for late stage lung cancer from the serum samples. This selected protein markers can predict metastasis of lung cancer patients.