Relationship of P-AKT abnormal expression with angiogenesis in follicular thyroid carcinoma

VernacularTitle:甲状腺滤泡癌P-AKT表达异常与血管生成的关系
Author: Peng ZHAO ; Fangfang JI ; Yangang WANG
Publication Type:Journal Article
Keywords: Thyroid neoplasms; P-AKT; Angiogenesis; Immunohistochemistry
From: Cancer Research and Clinic 2009;21(6):377-379
CountryChina
Language:Chinese
Abstract: Objective To study the abnormal expression of P-AKT in follicular thyroid carcinoma and its relationship with angiogenesis. Methods MVD and expressions of P-AKT, VEGF in 40 specimens of FTC tissues were detected by immunohistochemical PV6000 method. Results The expression rate of P-AKT in FTC was higher than that of non-FTC tissues. The result was of statistical significance (P<0.001). There were correlations between the MVD of FTC tissue and the expression of P-AKT and VEGF (P<0.05). The MVD of P-AKT positive FTC tissue was higher than that of negative tissues (P<0.05). The MVD of VEGF positive FTC tissue was also higher than that of negative tissues(P<0.05). There were correlations between the expression of P-AKT and VEGF(P<0.05). Conclusion The hyperexpression of P-AKT played an important role in the secondary deposits and development of human follicular thyroid carcinoma. AKT/VEGF pathway may exist in FTC, and AKT is the key factor in the pathway which regulated the expression of VEGF.