Clinical significance of anti-β2glycoprotein I antibodies in systemic lupus erythematosus
10.3760/cma.j.issn.0254-5101.2009.07.017
- VernacularTitle:系统性红斑狼疮患者抗β2-糖蛋白Ⅰ抗体检测及其临床意义
- Author:
Weidong JIN
;
Limin GONG
;
Yongjian CHEN
;
Fang SU
;
Yasong LI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Auto antibodies;
Anti-β2 glyeoprotein Ⅰ antibodies;
Enzyme-linked immunesorbent assay
- From:
Chinese Journal of Microbiology and Immunology
2009;29(7):646-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application of anti-β2 glyeoprotein Ⅰ antibodies (IgG, IgM, IgA)in systemic lupus erythematosus(SLE). Methods The anti-β2-GP Ⅰ antibodies and anti-cardiolipin antibodies(ACL) level were measured by ELISA in 100 SLE patients, 39 other rheumatoid arthri-tis patients and 30 healthy control people. Their clinical application was analyzed in SLE diagnose and thera-py. Results The level of anti-β2-GP Ⅰ (IgG, IgM, IgA)were significantly higher in SLE than that in healthy (P < 0. 01 ). Sensitivity, specificity, positive predictive value and negative predictive value were 17.2%, 95.7%, 85.0% and 44. 6%, respectively. There was a significant and positive correlation be-tween anti-β2-GP Ⅰ antibodies and ACL antibodies ( IgG, IgM, IgA) (r = 0.418, 0. 624, 0.518, 0. 583, P <0.01). In multivariate analysis the factors(anti-β2-GP Ⅰ antibodies, ACL antibodies, dsDAN, u1-RNP, Sm, SSA, SSB, Jo-1, Scl-70, P-protein, PT, APTT) associated with SLE disease activity index(SLEDAI) were anti-β2-GP Ⅰ (IgG) and dsDNA. Conclusion anti-β2-GP Ⅰ antibody has high specificity and positive predict value, also is associated with SLE's thrombosis. It has some values in the clinical application.
