Association between non-dipping circadian blood pressure rhythm and left ventricular hypertrophy in chronic kidney disease patients
10.3760/cma.j.issn.1001-7097.2009.09.001
- VernacularTitle:慢性肾脏病患者血压非勺型节律与左心室肥厚之间的关系
- Author:
Xiajing CHE
;
Zhaohui NI
;
Weiming ZHANG
;
Minfang ZHANG
;
Leyi GU
;
Yucheng YAN
;
Hua YING
;
Chunhua HU
;
Jiaqi QIAN
- Publication Type:Journal Article
- Keywords:
Kidney disease;
Blood pressure monitoring;
ambulatory;
Circadian rhythm;
Left ventricular hypertrophy
- From:
Chinese Journal of Nephrology
2009;25(9):663-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the association between non-dipping circadian blood pressure (BP) rhythm and left ventrieular hypertrophy (LVH) in chronic kidney disease (CKD) patients. Methods A total of 257 CKD patients of stage 1 to 5 were enrolled in the study. The parameters of BP and circadian rhythm were measured by ambulatory BP monitoring (ABPM) and the cardiac structure was examined by echocardiography. The association between circadian BP rhythm and echocardiographic parameters was studied. Results The prevalence of abnormal circadian BP rhythm (non-dipping rhythm) was quite high (75.4%) in CKD patients and increased with the deterioration of renal function. Even if in the normal BP group, the prevalence of non-dipping rhythm was 71.3%. The change of cardiac structure such as LVH in non-dipping patients was more obvious than the dipping patients. The left ventrieular mass index (LVMI) was positively correlated with BP, non-dipping rhythm. Multiple regression analysis showed that 24 h-SBP (β=0.417, P<0.01), triglyceride (TG) (β=-0.132, P=O.007), Hb (β=-0.394, P=0.016) and gender(β=0.158, P=0.039) were independent risk factors of LVMI. Conclusions The prevalence of non-dipping rhythm is quite high in CKD patients and increases with the deterioration of renal function. The change of cardiac structure such as LVH is obvious in CKD patients, especially in non-dipping group. The non-dipping rhythm is related with LVMI.
