Measurement of microvessel density (MVD)and its relationship with expression of survivin mRNA in pathologic scar
10.3760/cma.j.issn.1671-0290.2009.04.017
- VernacularTitle:病理性瘢痕组织中微血管密度的测定及与survivin mRNA的表达关系
- Author:
Guangshuai LI
;
Linbo LIU
;
Xiaomei ZHAI
;
Yantang CHEN
- Publication Type:Journal Article
- Keywords:
Pathologic scar;
Survivin mRNA;
CD105;
Microvesiel density
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2009;15(4):264-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mierovessel density (MVD) marked by CD105 and expression of survivin gene in pathologic scar, and to investigate the function of oncogenes in tumorigenic process and abnormal scarring. Methods In situ hybridization and immunohistoehemical methods (SP technique) were used to detect survivin mRNA, CD105-MVD in 40 pathologic scar cases, 20 normotrophic scar cases, and 20 normal skin cases, respectively. The relationship between the expression of survivin mRNA and CD105-MVD in 40 pathologic scar cases were analyzed. Results Compared with normotrophic scar and normal skin cases, the expression of survivin mRNA, CD105-MVD were significant difference in pathologic scar cases (P<0.05). In pathologic scar tissue, the expression of survivin had significant correlation with MVD marked by CD105 (P<0.05). Conclusion survivin is up-regulated in pathologic scar, which may contribute to the vascular formation.
