Influence of factors on long-term survival of stage Ⅰ NSCLC by detection of micrometastatic tumor cells in pNO lymph nodes
10.3760/cma.j.issn.1006-9801.2009.06.009
- VernacularTitle:Ⅰ期非小细胞肺癌淋巴结微转移及临床特征对长期生存的影响
- Author:
Junwang ZHANG
;
Ti DING
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Neoplasm metastasis;
Disease-free survival
- From:
Cancer Research and Clinic
2009;21(6):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of some factors on long-term survival of postoperative stage Ⅰ NSCLC patients. Methods 91 patients of NSCLC who underwent radical surgery of the primary tumor with dissection of the hilar and mediastinal lymph nodes were diagnosed as stage Ⅰ NSCLC postoperatively by pathology and followed up for 5 years. Its hilar and subcarinal lymph nodes were detected occult micrometastastic tumor cells by immunohistochemistry (SP method) by using the binoclonal antibody multicytokeratin (AE1/AE3) as a micrometastatic marker. To analyse the influence of micrometastasis and the clinicopathologic characteristics on long-term survivals. Results The rate of micromatastasis of stage Ⅰ NSCLC was 49 %. The five-year overall survival rate was 70.3 %. The median of survival time was 48.5months. The rate of metastasis was 32 % and the meantime of relapse and metastasis was 36.6months. Tumor size, differentiation, stage, and micrometastasis were significantly associated with relapse and metastasis (P <0.05). The tumor differentiation, stage, and micrometastasis were found to be significant independent factor on survival in multivariate analysis (P<0.05). Conclusion There was nodal micrometastasis in completely resected stage Ⅰ NSCLC, and the tumor differentiation, stage, and micrometastasis were found to be significant independent factor on survival.
