Expressions of Smad3 and Smad7 in colonic mucosa of patients with ulcerative colitis
10.3760/cma.j.issn.0254-1432.2009.10.005
- VernacularTitle:溃疡性结肠炎患者结肠黏膜中Smad3和Smad7表达的研究
- Author:
Wenjun WEI
;
Jianming XU
;
Qiao MEI
;
Haitao TANG
- Publication Type:Journal Article
- Keywords:
Colitis,ulcerative,Smad proteins;
Immunohistochemistry
- From:
Chinese Journal of Digestion
2009;29(10):662-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Smad3 and Smad7 in patients with ulcerative colitis(UC)and their relation with clinicopathology.Methods The expressions of Smad3 and Smad7 were measured by immunohistochemistry with SABC method in 60 UC specimens and 16 normal colonic tissues.The association of expressions of Smad3 and Smad7 proteins with clinical staging,lesion extent and pathologic grading were retrospectively analyzed.Results The expression of Smad3 was significantly lower in UC patients than in normal controls(P＜0.05),however,there was no relation between Smad3 expression and lesion extent(P＞0.05).There was a negative correlation between the expression of Smad3 and histological grade(r=-0.283,P＜0.05).The expression of Smad7 was significantly higher in UC patients than in normal controls,and its expression in active disease was higher than that in clinical remission(Z=2.097,P=0.036).There was a positive correlation between the expression of Smad7 and histological grade(r_s=0.453,P=0.000),and no relation between Smad7 expression and lesion extent(r_s=0.066,P=0.614).The statistical analysis showed a negative correlation between Smad3 expression and Smad7 expression(r=-0.420,P＜0.05).Conclusion The abnormal expressions of Smad3 and Smad7 are correlated with pathogenesis of UC.Furthermore.Smad7 may serve as marker for disease activity of UC.
