The effects of local wet hyperthermia combined with microwave ablation on tumor growth and serum levels of interferon-β and interleukine-12 in mouse models of mammary carcinoma
10.3760/cma.j.issn.0254-1424.2009.09.008
- VernacularTitle:局部湿热联合微波消融对乳腺癌荷瘤小鼠肿瘤生长和血清干扰素-γ、白细胞介素-12的影响
- Author:
Ya ZHOU
;
Lin XU
;
Shehua REN
- Publication Type:Journal Article
- Keywords:
Local wet hyperthermia;
Microwave ablation;
Tumor metastasis
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(9):604-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of local wet hyperthermia combined with microwave ablationon tumor growth and serum levels of interferon-β(IFN-β)and interleukine-12(IL-12).Methods An experimental mouse model beating mammary carcinoma was established in Balb/c mice and then treated with microwave ablation after 14 d.Seven d after ablation,local wet hyperthermia was administered once weekly for 2 weeks.Tumor growth and lung metastasis,as well as the survival of bearing tumor mice were observed.The serum levels of IFN-β and IL-12 were detected with enzyme-linked immuno sorbent assay(ELISA). Results When local wet hyperthermia was combined with microwave ablation tumor growth and lung metastasis were significantly less than when microwave ablation or local wet hyperthermia was used alone(P＜0.05).Furthermore,the survival of bearing tumor mice in combined therapy group prolonged significantly compared with those receiving either therapy alone(P＜0.05).Serum levels of IFN-β and IL-12 were also significantly higher in combined therapy group compared with the other groups (P＜0.05). Conclusions Local wet hyperthermia combined with microwave ablation is more effective than either local wet hyperthermia or microwave ablation alone in retarding tumor growth,which may be related to the enhanced immune response.
