The expression of TLR4 in fiver cell treated with cyst fluid of Echinocaccus granulosus
10.3760/cma.j.issn.0254-5101.2009.09.022
- VernacularTitle:细粒棘球蚴囊液对肝细胞表面TLR4表达的调节
- Author:
Yalou ZHANG
;
He HUANG
;
Quanhua FANG
;
Tao LIU
;
Zhihai PEN
;
Liang LI
;
Hao WEN
- Publication Type:Journal Article
- Keywords:
Echinococcus granulosus;
Cyst fluid;
Toll-like receptor;
Innate immunity
- From:
Chinese Journal of Microbiology and Immunology
2009;29(9):858-860
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the signal transduction pathway of cyst fluid of Echinococcus granalosus in anti-parasite mechanisms through investigating the effect of cyst fluid on the expression of Toll-like receptor(TLR) in cells. Methods Changes of TLR4 and TGF-β1 expression of 7404 liver cells were detected by quantitative PCR. Results After treatment with increasing concentration cyst fluid the expres-sion of TLR4 was reduced. TGF-β1 expression of liver cells increased with the dose. TLR2 expressions in each group were very low. Conclusion Cyst fluid can increase the expression of TLR4, suggesting that the TLR4 signal transduction pathway involve anti-cyst fluid of Echinococcus granulosus. High concentrations of cyst fluid contribute to TGF-β1 expression which plays a role in immune evasion.
