Effects of low-frequency electrical stimulation on motor function and the expression of glia fibrillary acidic protein around cerebral infraction sites
10.3760/cma.j.issn.0254-1424.2009.10.003
- VernacularTitle:低频电刺激对急性局灶性脑梗死大鼠运动功能及梗死边缘区胶质纤维酸性蛋白表达的影响
- Author:
Yuan PENG
;
Tiebin YAN
;
Dongmei JIN
;
Zhiqiang ZHUANG
;
Yun XIANG
;
Huihua LIU
;
Xiuyuan ZHENG
- Publication Type:Journal Article
- Keywords:
Low-frequency electric stimulation;
Cerebral infarction;
Motor function;
Glia fibrillary acidic protein
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(10):655-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of low-frequency electrical stimulation(LFES)on motor function and the expression of glia fibrillary acidic protein(GFAP)around cerebral infarction sites in rats.Methods Fifty-four male adult Sprague-Dawley rats were randomly divided into a LFES group,a placebo group and a sham operation group(18/group).All groups were randomly divided into 3 treatment groups.A rat model of middle cerebral artery occlusion(MCAO)was established using intraluminal filament occlusion.Treatment was carried out 3 d after the operation.Rats in the LFES treatment groups were stimulated with LFES for 3,7 or 14 days (10 min/d);the placebo groups were treated in the same way without electric stimulation;the sham operation subgroups didn't receive any therapy.Scores on a beam-walking test,a rotating pole test and a screen test were assessed at each time point mentioned above.Expression of GFAP was also assessed using immunohistochemcal techniques.Results The paralysed limbs recovered motor function better in the LFES groups than in the control groups.GFAP-positive cells were more numerous at the margins of the infarction area in the treated groups than in the control groups.Conclusions LFES might increase the expression of GFAP,which might be an important mechanism in improving brain plasticity after cerebral ischemia,aiding the recovery of the central nervous system and rebuilding its functioning.
