The cell type of renal allograft intimal arteritis and its relationship with peritubular capillaries C4d deposition
10.3760/cma.j.issn.1001-7097.2009.09.004
- VernacularTitle:移植肾动脉内膜炎的细胞类型及其与管周毛细血管C4d沉积的关系
- Author:
Juan JIN
;
Huiping WANG
;
Qiang HE
;
Jie ZHAO
;
Yan BI
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Graft rejection;
Endarteritis;
Macrophages;
T-lymphocytes;
Acute vascular rejection;
C4d
- From:
Chinese Journal of Nephrology
2009;25(9):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cell types of renal allograft intimal arteritis in posttransplantation patients and its relationship with peritubular capillaries (PTCs)C4d deposition. Methods Twenty allograft kidney transplant recipients from Jun 2006 to Jun 2008 were enrolled in the retrospective study. Twenty-one biopsy specimens with acute vascular rejection were immunostained for macrophages, T cells and C4d. In each biopsy specimen, arterial intimal macmphages and T cells were counted, and mean number of macrophages per "artery and T cells per artery were determined. The recipients were divided into C4d + and C4d- group according to whether C4d deposition in the PTCs. Results In the intimal arteritis of biopsies diagnosed as acute vascular rejection, the infiltrating cells were predominantly macrophages including C4d+ and C4d- group. T cells were the minority. The mean macrophage number per artery cross-section was significantly higher than the mean T cell number per artery cross-section in the C4d + group (12.45±9.86 vs 3.91±3.03, P=0.007) and in the C4d- group (3.47±1.89 vs 1.45±1.37, P=0.006). Forther more, the mean number of macrophage per artery cross-section in the C4d+ group was significantly higher than that in the C4d- group (P=0.007). Conclusions In the intimal arteritis of biopsies diagnosed as acute vascular rejection, the infiltrating cells are predominantly macrophages which has relationship with peritubular capillary C4d deposition. The mean number of macmphage per artery cross-section in the C4d+ biopsies is significantly higher than that in the C4d- biopses.
