Correlation of expressions of MMP-2 and MMP-9 in the transitional cell carcinoma of bladder with tremor invasion and metastasis

VernacularTitle:基质金属蛋白酶2和9在膀胱移行细胞癌中的表达及其意义
Author: Feng ZHU ; Yan ZHANG ; Rui YAN ; Huiqing ZHANG ; Yingjie ZHANG
Publication Type:Journal Article
Keywords: Urinary bladder neoplasms; Matrix metalloproteinase-2; Matrix metalloproteinase-9; Immunohistochemistry
From: Cancer Research and Clinic 2009;21(10):680-682
CountryChina
Language:Chinese
Abstract: Objective To evaluate the expression of MMP-2 and MMP-9 and their relation with tumor invasion and metastasis in transitional cell carcinoma of bladder (TCCB). Methods Immunohistochemistry of EliVision were respectively used to determine the MMP-2 and MMP-9 expression in tumor tissues of 46 patients with TCCB and 14 cases of control group which were screened quantitatively (3-5 cm of surrounding tumor) between August 2006 and August 2008. Results Expression of MMP-2 and MMP-9 in TCCB are obviously higher than the normal control group (P <0.01), expressions of MMP-2 and MMP-9 in level Ⅱ,Ⅲ are obviously higher than in level Ⅰ (P <0.01), but there was no significant relationship between high stage or level Ⅲ and low stage or level Ⅱ (P >0.05). Conclusion The positive expressions of MMP-2 and MMP-9 in tumor tissues correlated with the malignant degree, invasion and metastasis of TCCB, MMP-2, MMP-9 could be useful indicators for the assessment of prognosis of TCCB.