The cell of origin of human retinoblastoma
10.3760/cma.j.issn.1015-1005.2009.06.02
- VernacularTitle:人类视网膜母细胞瘤的细胞起源
- Author:
Danian CHEN
- Publication Type:Journal Article
- Keywords:
Retinoblastoma/pathophysiology;
Genes;
retinoblastoma/physiology;
Retinoblastoma protein;
Cones (retina)/pathology;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2009;25(6):413-415
- CountryChina
- Language:Chinese
-
Abstract:
The debate on the cell of origin of human retinoblastoma lasted for more than one century.In the recent issue of "cell",David Cobrinik's group shows that L/M cone precursors are the most likely answer as they have an intrinsic circuitry,including murine double minute 2 (MDM2),N-myc,the nuclear receptors retinoid X receptor and thyroxine receptor 2,making them extremely sensitive to transformation following retinoblastoma gene inactivation.
