The effects of hyperbaric oxygenation therapy on serum cytokines and depression in post-stroke depression
10.3760/cma.j.issn.0254-1424.2009.10.006
- VernacularTitle:高压氧辅助治疗对脑卒中后抑郁患者血清细胞因子及抑郁状态的影响及其临床意义
- Author:
Zhijun YOU
;
Chengyan LI
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygenation;
Post-stroke depression;
Tumor necrosis factor-α;
Interleukin-1β
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(10):667-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygenation(HBO)therapy on serum cytokines and depression in post-stroke depression(PSD)and to study it's clinical implications.Methods Sixty patients with PSD were divided into two groups.Patients in routine treatment group(RT group)were treated with routine clinical treatment,whereas those in HBO group were treated with HBO therapy in addition to routine clinical treatment.The serum cytokines of tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were measured by enzyme-linked immunosorbent assay(ELISA)before and after 30 days of treatment.All the patients were evaluated with Hamilton depression scale(HAMD),Chinese stroke scale(CSS)and Barthel index(BI).The evaluations were carried out at the 0 and 30 d.Results Before treatment,the concentrations of TNF-α and IL-1β in patients with PSD were significantly higher than those in patients with cerebral infarction without depression(P＜0.01),and the serum levels of TNF-α and IL-1β in those with serious depression were higher than those with moderate and mild depression(P＜0.01),and that in moderate depression patients were higher than that in mild depression patients{P＜0.01).At the 30th d post-treatment,those parameters all decreased significantly in RT group and HBO group(P＜0.01,P＜0.05).Moreover,those parameters were lower in HBO group than those in RT group(P＜0.01),and HAMD,CSS and BI scores in HBO group were significantly better than that in RT group(P＜0.05,P＜0.01).Conclusions Serum cytokines levels increased significantly in patients with PSD and were associated with the severity of depression.Serum cytokines might played an important role in pathogenesis of PSD.HBO therapy could help decrease the levels of TNF-α and IL-1β.HBO might exert therapeutic effect by reducing secondary the inflammatory injury in acute cerebral infarction.
