The study progress of HSP-105 in tumor on applied and basic research fields
10.3760/cma.j.issn.1006-9801.2009.10.026
- VernacularTitle:热休克蛋白105在肿瘤应用基础领域的研究进展
- Author:
Hongjun GAO
;
Xiaohang ZHAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
second primary;
Heat-shock proteins;
Antigens;
neoplasm
- From:
Cancer Research and Clinic
2009;21(10):713-715
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein (HSP) 105 is a 105x103 stress protein that belongs to the HSP-110 family. It is released by tissues in response to a wide variety of stresses including infection and ischaemia. Studies have shown that the molecule is involved as a biochemical mediator of heat induced apoptosis by binding to p53 at scrotal temperatures and dissociating from it at suprascrotal temperatures in testicular germ cells. Recent studies have shown that HSP-105 is over-expressed in various malignancies besides in normal testicular tissue. HSP-105 may be a candidate of testis antigen.
