Effect of 15-deoxy-△~(12,14)-prostagliandxin J2 on hypertrophic scar in rabbit ear
10.3760/cma.j.issn.1671-0290.2010.01.013
- VernacularTitle:15-脱氧-△~(12,14)-前列腺素J2对兔耳增生性瘢痕的作用
- Author:
Shu PAN
;
Yeyang LI
;
Li FANG
;
Peihong LIANG
;
Libing DAI
;
Jianping LI
;
Yan ZHANG
;
Gang LI
;
Tao ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertrophic scar;
Peroxisome proliferator activated receptor-r;
PPAR-r;
Collagen type Ⅰ;
Connective tissue growth factor;
CTGF;
a-Smooth muscle actin;
a-SMA
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2010;16(1):41-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of 15d-PGJ2 on the expression of collagen type,CTGF and a-SMA in the hypertrophic scar in the rabbit ear,and the possibility of hypertrophic scar treated by 15d-PGJ2.Methods 18 New Zealand white rabbits were used to establish a hypertrophic scar model on the rabbit ear.The wounds were established as follows:2 cm × 3 cm wounds with total skin loses on the ventral side,2 wounds for each ear,totally 72 wounds.The wounds were randomly divided into the 15d-PGJ2 treatment group and NS control group.20μl 15d-PGJ2 or NS was injected into the ear scar once a day for 7 days.At 7,14 and 21 days after the injection,12 scars of each group were harvested.The expression of collagen type Ⅰ,CTGF and a-SMA was detected by immunohistochemical method.Results Excessive dermal scars on rabbit ears that were similar to human hypertrophic scar appeared in the two groups.Compared with the NS-treated scars group,the 15d-PGJ2-treated scars appeared to be smaller,softer,flatter and lighter in color.The expression of collagen type Ⅰ,CTGF and a-SMA in the 15d-PGJ2 group was significantly decreased as compared with that in the control group at different time points(P＜0.05).Conclusion 15d-PGJ2,the ligand of PPAR-r,can reduce the expression of collagen type Ⅰ,CTGF and a-SMA of hypertrophic scar in the rabbit ears and plays an important role in the prevention and treatment of hypertrophic scar.It may provide a new approach for the treatment of hypertrophic scar in clinical setting.
