Effect of platelet derived growth factor on fibroblasts of scars

VernacularTitle:血小板源生长因子对瘢痕成纤维细胞的影响
Author: Ruihong YUAN ; Liu LIU ; Deping ZHAO ; Honghui XU ; Jiaping SUN ; Fuke WANG ; Jing MA
Publication Type:Journal Article
Keywords: Scar; Cytokine; Fibroblast; Wound healing; Platelet derived growth factor; PDGF
From: Chinese Journal of Medical Aesthetics and Cosmetology 2010;16(1):38-40
CountryChina
Language:Chinese
Abstract: Objective To explore the mechanism of cytokines for the scars,and to study the effect of platelet derived growth factor(PDGF)on the biological behavior of fibroblasts in scars.Methods Fibroblasts of scars and normal skins were cultured in vitro.The results were observed and analyzed by light inverted microscopy(LM),and 3-(4,5-dimethyl-thiazol-2-yl)-2,5 ciphenyl tetrazolium bromide (MTT)assay.The effects of PDGF on the biological behaviors of fibroblasts of scars were also determined. Results In vitro study,using LM,FCM and MTT assay,showed that proliferation of fibroblasts were inereased significantly when PDGF was added to the cultures,as compared to the control groups.Conclusions PDGF can increase fibroblast proliferation.These results demonstrate that PDGF is beneficial for wound healing at early stage.