Expression and correlation of ABCG2 and V-ATPase in NSCLC
10.3760/cma.j.issn.1006-9801.2009.12.005
- VernacularTitle:ABCG2与空泡型ATP酶在非小细胞肺癌中的表达及其相关性
- Author:
Boya LIU
;
Zhipei ZHANG
;
Xiaofei LI
;
Yingchun DENG
;
Kunxiang GAO
;
Hong XU
;
Peng WANG
;
Qingshu CHENG
- Publication Type:Journal Article
- Keywords:
Carcinoma;
non-small-cell lung;
Adenosine triphosphatases;
ABCG2
- From:
Cancer Research and Clinic
2009;21(12):806-809
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of ABCG2 and V-ATPase in NSCLC and their expression rates in pathological classification, TNM stages and pathological grades and the expression correlation between ABCG2 and V-ATPase. Methods Expressions of ABCG2 and V-ATPase were accessed with EnVinsion immunohistochemistry in tumor samples from 92 NSCLC patients. The corresponding data was analyzed statistically. Results Expressions of ABCG2 and V -ATPase were found both in the lung adenocarcinoma and lung squamous cell cancer, and the difference between these two kinds of tumors was significant (P =0.003,0.000). ABCG2 expression was significantly different among TNM stages of lung adenocarcinoma (P=0.004) as well as among pathological grades of lung adenocarcinoma (P =0.028) and squamous cell carcinoma (P =0.000), while no significant difference was found among TNM stages of squamous cell lung carcinoma. The level of V-ATPase expression was associated with TNM stages of lung adenocarcinoma (P =0.026) and pathological grades of lung squamous cell carcinoma (P =0.002), however, among TNM stages of lung squamous cell carcinoma and pathological grades of lung adenocarcinoma, the difference was not significant. Additionally, the significant correlation was found between expression of ABCG2 and V-ATPase in all samples, adenocarcinoma and squamous cell carcinoma (P<0.001). Conclusion The significant correlation is found between expression of ABCG2 and V-ATPase, which indicate that they may co-work to participate in the mechanism of anticancer drug resistance.
