Strategy and clinical translational advances of targeting the costimulatory molecule CD_(40)/CD_(40L) for neoplasm therapy

VernacularTitle:共刺激分子CD_(40)/CD_(40L)靶向治疗的策略及应用进展
Author: Songbing HE ; Liang WANG ; Dechun LI
Publication Type:Journal Article
Keywords: Neoplasms; Antigens; CD_(40); Therapy
From: Cancer Research and Clinic 2009;21(12):860-862
CountryChina
Language:Chinese
Abstract: Costimulatory molecule CD_(40) is extensively expressed by immune, hematopoietic, epithelial, and a wide range of tumor cells. As a potential target for novel cancer therapy, CD_(40)/CD_(40L) may mediate tumor regression through both an indirect effect of immune activation and a direct cytotoxic effect on the tumor. Several drug formulations that target the CD_(40)/CD_(40L) pathway have undergone phase I clinical evaluation in advanced-stage cancer patients, and initial findings show objective clinical responses immune modulation function and have not serious toxicity.