Application of RNA interference in xenografted tumor of nude mice in vivo
10.3760/cma.j.issn.1006-9801.2009.12.028
- VernacularTitle:RNA干扰技术在裸鼠移植瘤中的应用
- Author:
Jingchun WANG
;
Huimin WANG
- Publication Type:Journal Article
- Keywords:
RNA interference;
Genes;
Antineoplastic protocols
- From:
Cancer Research and Clinic
2009;21(12):862-864
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference (RNAi) is a post-transcriptional suppression method of introduction of double-stranded RNA molecules by artificially induced. Recently RNAi has been widely used in xenografted tumors of nude mice in vivo. In order to inhibit the growth of tumor, some genes related with tumor such as anti -apoptosis gene, proliferation promoting gene, metastasis-associated gene are depressed via RNAi. Additionally, in the nude mice test, RNAi is utilized as assisting methed of radiotherapy and chemotherapy of human tumors.
