Influence of different reference GFR distribution on racial coefficient in GFR estimating equation
10.3760/cma.j.issn.1001-7097.2009.12.002
- VernacularTitle:肾小球滤过率测量值分布对估计公式中种族系数的影响
- Author:
Xinju ZHAO
;
Jianghua CHEN
;
Qiong LUO
;
Xueqing YU
;
Ying LI
;
Jinsheng XU
;
Songmin HUANG
;
Lining WANG
;
Wen HUANG
;
Mei WANG
;
Yingchun MA
;
Li ZUO
;
Guobin XU
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Glomerular filtration rate;
Continental population groups;
Renal insufficiency;
chronic;
Racial coefficient;
GFR estimating equation
- From:
Chinese Journal of Nephrology
2009;25(12):890-895
- CountryChina
- Language:Chinese
-
Abstract:
Objective To illustrate if the racial coefficient (Rc) be biased by different reference GFR (rGFR) distribution among studies. Methods 1405 white and 321 African American participants in MDRD study and 684 chronic kidney disease(CKD)patients in Chinese eGFR Investigation Study were included.Firstly.the unweighted datasets of white and Chinese were stacked together.rGFR,age and plasma creatinine (Pcr) were log transformed.Linear regression model was constructed using log transformed rGFR as dependent,gender,race and log transformed Pcr and age as independent.Unweighted RC (uRC) for Chinese was calculated.Then.the Chinese CKD distribution of rGFR was weighted to be the same as that in White American.and weighted RC (wRC)for Chinese was calculated.The cases of White.and African-American were stacked together.The cases of African-American were weighted to make the rGFR distribution the same as that in White-American and Chinese population respectively,and RCs for African-American were calculated. Resuits The uRC for Chinese was 1.197(1.180-1.211)and the wRC was 1.130 (1.117-1.143).The two RCs did not overlap with each other.The RCs for African-American were 1.205(1.19-1.219)and 1.233(1.219-1.247)respectively. Conclusions The RCs were influenced by the difference of rGFR distribution.To find out the real RC.an intemational collaborative study iS needed,with the same rGFR measure method.strict control of Pcr measurement,and the same rGFR distribution.
