Phenotype of Chinese patients with Gitelman syndrome and the effect of gender on the Phenotype
10.3760/cma.j.issn.1001-7097.2009.07.011
- VernacularTitle:Gitelman综合征的表型特点及性别因素对表型的影响
- Author:
Ling QIN
;
Leping SHAO
;
Hong REN
;
Weiming WANG
;
Wen ZHANG
;
Nan CHEN
- Publication Type:Journal Article
- Keywords:
Gitelman syndrome;
Phenotype;
Mutation;
Gender
- From:
Chinese Journal of Nephrology
2009;25(7):532-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features and the effect of gender differences on phenotype of Giteiman syndrome (GS) patients. Methods Clinical features and biochemical parameters were compared and analyzed to look for correlation between male and female GS patients. Results More male patients suffered from nocturia than female patients (P < 0.05), and there were no statistical differences in other clinical features between males and females. The level of serum creatinine was higher in male patients than that in female ones [(82.7±43.3) μmol/L vs (58.7±12.7) μmol/L], but estimated glomerular filtration rate was male patients and female patients. The urinary potassium and chloride excretion fraction were higher in male group than those in female group (33.0%±22.9% vs 17.0%±4.7%;2.30%±1.59% vs 1.23%±0.39%, P< 0.05, respectively). Statistical differences were not observed in other laberatory parameters. Three patients with impaired renal function were all male. Conclusions More male patients suffer from nocturia than female patients. Male patients seem to be prone to impaired renal function. It is speculated that different density of sodium-chloride cotransporter in renal tubule may account for gender differences.
