Expression of let-7a2 in lung adenocarcinoma
10.3760/cma.j.issn.1006-9801.2010.01.015
- VernacularTitle:let-7a2在肺腺癌中表达状况的研究
- Author:
Xiaoming XIA
;
Weiyun JIN
;
Renzhong SHI
;
Yafeng ZHANG
;
Jun CHEN
- Publication Type:Journal Article
- Keywords:
Micro RNAs;
Lung neoplasms;
let-7;
Gene expression
- From:
Cancer Research and Clinic
2010;22(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of let-7a2 in lung adenocarcinoma.Methods To adapt technology of realtime PCR with reference of U6, the expression of let-7a2 in tumor tissues and normal tissues was detected in 15 cases of resected lung adenocarcinoma. The laboratorial data were analysed by measure of 2~(-△△CT) method. The analysed data were managed by statistics. Results The expression of let-7a2 in lung adenocarcinoma tissue was significantly lower than that in lung normal tissue (0.8733±0.4821 vs 2.4527±1.0111). This difference possess markedness significance(t=6.816, P<0.001).Conclusion The expression of let-7a2 in lung adenocarcinoma is obviously lower and is concerned with the course of lung cancer evolution.
