Preliminary observation on anti-tumor necrosis factor α therapy in fulminant ulcerative colitis

VernacularTitle:肿瘤坏死因子拮抗疗法对暴发型溃疡性结肠炎诱导缓解的初步探讨
Author: Jianxin WU ; Minhong ZHANG ; Yuanwen CHEN ; Wensong GE ; Yunlan ZHOU ; Jiangao FAN
Publication Type:Journal Article
Keywords: Ulcerative colitis; Infliximab; Tumor necrosis factor-alpha; Mucous; Wound healing
From: Chinese Journal of Digestion 2010;30(2):87-89
CountryChina
Language:Chinese
Abstract: Objective To report three cases of fulminant ulcerative colitis (FUC) treated with infliximab (IFX) and the positive result for clinical purpose. Methods Three patients with FUC were infused with IFX (5 mg/kg) at interval of 0, 2, 6 wk. Sulfasalazine or probiotics was used for the maintanance of remission. The mucosal healing was evaluated by endoscopy and patholoic examination. ResultsComplete remission was found in 3 patients with FUC. Eight weeks after IFX withdraw, complete remission was found in two of three cases demonstrated by endoscopy, except for one case died from refractory ventricular tachycardia. The remaing 2 cases showed no active manifestation during 8 months' follow-up. Conclusion IFX therapy results in complete remission in 3 cases with FUC. However, further randomized control study is warranted for concrete evaluation on salty and application clinically.