Research progress on the antitumor immuoregulation of CpG ODN induced dendritic cell

VernacularTitle:CpG ODN诱导树突状细胞抗肿瘤作用的研究进展
Author: Tiye SUN ; Wei YAN ; Ningxin ZHOU
Publication Type:Journal Article
Keywords: Oligonuceotides; Dendritic cells; Immunity; Immunoregulation
From: Cancer Research and Clinic 2010;22(1):67-69
CountryChina
Language:Chinese
Abstract: Oligodeoxynucleotides containing CpG motifs have shown powerful immunoregulation effects, which are able to activate a variety of immune cells such as natural killer (NK) cells, monocytes,macrophages, dendritic cells(DC), B and T lymphocytes. CpG oligodeoxynucleotides (CpG ODN) can not only induce and enhance nonspecific and specific immune responses, but also regulate the type of immune responses through inducing Th1-type immune response and suppressing Th2-type immune response. DC are known to be the most powerful special antigen-presenting cells (APC) at present. It plays an important role in antigen recognition,antigen processing presenting, and T cell activation, and can kill various kinds of tumor cells. Recently, the immunotherapy based on tumor vaccines of dendritic cell has become more and more important. The research progress on dendritic cells for cancer treatment is reviewed in this article.