Immunomodulatory activity of cancer chemotherapy
10.3760/cma.j.issn.1006-9801.2010.01.025
- VernacularTitle:化学疗法对肿瘤的分子免疫调控研究
- Author:
Jie LI
;
Hongsheng LIN
;
Guizhi SUN
- Publication Type:Journal Article
- Keywords:
Drug therapy,combination;
Immunity;
Molecular mechanisms of action
- From:
Cancer Research and Clinic
2010;22(1):70-72
- CountryChina
- Language:Chinese
-
Abstract:
In addition to kill tumor cells through direct cytotoxicity, the immunomodulatory activity is another facet of chemotherapy. The major molecular mechanisms of immunogenicity of cytotoxic drugs are elimination of CD_4~+ CD_(25)~+ regulatory T cells or Myeloid-Derived Suppressor Cells, and sensitization of tumor cells to immune effectors through modulation of death receptor expression. These studies provide scientific evidence for combinatorial treatments including vaccines and Traditional Chinese Medicine for cancer therapy.
